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KMID : 0360320010330060463
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Journal of Korean Cancer Research Association
2001 Volume.33 No. 6 p.463 ~ p.468
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Sarcoma and Sarcomatous Metaplastic Carcinoma of the Breast
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류상한/Sang Han Yu
노우철/방호윤/황대용/최동욱/이종인/백남선/문난모/정진행/Woo Chul Noh/Ho Yoon Bang/Dae Yong Hwang/Dong Wook Choi/Jong Inn Lee/Nam Sun Paik/Nan Mo Moon/Jin Haeng Chung
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Abstract
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PURPOSE:
Primary sarcoma and SMC (sarcomatous metaplastic carcinoma) of the breast are very rare tumors, accounting for less than 1% of all breast malignancies. There are many controversies concerning the biological characteristics, prognosis and optimal treatment of these tumors owing to the rarity of incidence. The aims of this study were to elucidate the clinicopathologic characteristics of these tumors and to assist in elucidating the optimal treatment plan for the disease.
MATERIALS AND METHODS:
13 cases of primary sarcoma and 10 cases of SMC that had been treated at KCCH between 1984 and 2001 were retrospectively reviewed. Phyllodes tumors were excluded from our study.
RESULTS:
Among the 13 cases of primary sarcoma included, stromal sarcoma occurred in 5 cases, osteosarcoma in 3 cases, angiosarcoma in 3 cases and spindle cell sarcoma in 2 cases. The mean age of the patients with primary sarcoma and SMC was 39.7 years and 55.1 years respectively (p=0.002). When survival rates were compared according to histologic types, size of tumor, histologic grade, type of surgery and use of adjuvant therapy, both size of tumor (p=0.0256) and histologic grade (p=0.0197) were shown to be prognostic factors.
CONCLUSION:
There were no significantly different features between primary sarcoma and SMC in terms of biologic characteristics or survival rates, with the exception that patients with SMC were older than those with primary sarcoma. Histologic grade and size of tumor were significant prognostic factors of these tumors.
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KEYWORD
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Breast neoplasm, Sarcoma, Sarcomatous metaplastic carcinoma,
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